Sony SH800 Cell Sorter
The Sutter P-1000 Horizontal Puller is an essential tool in biomedical research labs, particularly in electrophysiology and neurobiology. In my research on the nervous system, I use this device to produce precise micropipettes for patch-clamp recordings, a key technique for studying neuronal electrical activity. Studies investigating neurological disorders such as epilepsy, Alzheimer’s, and neurodegenerative diseases rely on high-quality electrodes to record single-cell activity, making the P-1000’s precision crucial. Its digital interface and programmable settings ensure consistent pipette fabrication, enhancing experiment reproducibility.
Additionally, the P-1000 is ideal for pulling injection needles for genetic manipulation in living cells. In CRISPR-Cas9 genome editing, we use it to prepare fine-tipped needles for injecting mRNA, DNA, or RNP complexes into neurons or early-stage embryos, improving efficiency and accuracy. It is also widely used in mouse model genetic engineering, where ultra-thin needles enable precise embryonic injections. With its high precision, user-friendly interface, and reproducibility, the P-1000 is an indispensable tool in advanced neuroscience, biotechnology, and genomics research.
Core Research Facilities | Site
Ein Karem
Bio Medicine Research Core Facility
Contacts
- Dr. Idit Hazan
- idith@ekmd.huji.ac.il